Complete Nucleotide Sequence of Plasmid pTN48, Encoding the CTX-M-14 Extended-Spectrum β-Lactamase from an Escherichia coli O102-ST405 Strain

Typhaine Billard-Pomares (1, 2) , Olivier Tenaillon (3, 4) , Hervé Le Nagard (5, 4) , Zoé Rouy (6) , Stéphane Cruveiller (6) , Claudine Médigue (6) , Guillaume Arlet (7, 8) , Erick Denamur (3, 4) , Catherine Branger (3, 2)

1 IAME (UMR_S_1137 / U1137) - Infection, Anti-microbiens, Modélisation, Evolution
2 Hôpital Louis Mourier - AP-HP [Colombes]
3 EEM - Ecologie et Evolution des Microorganismes
4 UPD7 - Université Paris Diderot - Paris 7
5 U738 / UMR_S738 - Modèles et méthodes de l'évaluation thérapeutique des maladies chroniques
6 UMR 8030 - Génomique métabolique
7 UPMC - Université Pierre et Marie Curie - Paris 6 - UFR de Médecine Pierre et Marie Curie
8 CHU Tenon [AP-HP]

The sequence of pTN48, a plasmid of the FII-FIB replicon type that encodes a CTX-M-14 enzyme in an Escherichia coli strain of the phylogenetic group D 2 O102-ST405 clone, was determined. pTN48 is, for the most part, a mosaic of virulence, antibiotic resistance, and addiction system modules found in various other plasmids. The presence of multiple addiction systems indicates that the plasmid should be stably maintained in the E. coli clone, favoring dissemination of the CTX-M-14 enzyme.

Domaines: Sciences du Vivant [q-bio]; Biologie cellulaire; Cancer; Microbiologie et Parasitologie

Typhaine Billard-Pomares, Olivier Tenaillon, Hervé Le Nagard, Zoé Rouy, Stéphane Cruveiller, et al.. Complete Nucleotide Sequence of Plasmid pTN48, Encoding the CTX-M-14 Extended-Spectrum β-Lactamase from an Escherichia coli O102-ST405 Strain. Antimicrobial Agents and Chemotherapy, 2011, 55 (3), pp.1270 - 1273. ⟨10.1128/aac.01108-10⟩. ⟨hal-04579228⟩