Preterm birth: A neuroinflammatory origin for metabolic diseases?

Sihao Diao (1) , Chao Chen (2, 3) , Alexandre Benani (4, 5) , Christophe Magnan (6) , Juliette van Steenwinckel (1) , Pierre Gressens (1) , Céline Cruciani-Guglielmacci (6) , Alice Jacquens (7, 1) , Cindy Bokobza (1)

1 NeuroDiderot (UMR_S_1141 / U1141) - Maladies neurodéveloppementales et neurovasculaires
2 Children's Hospital of Fudan University
3 Key Laboratory of Neonatal Diseases, National Health Commission
4 CSGA - Centre des Sciences du Goût et de l'Alimentation [Dijon]
5 UBFC - Université Bourgogne Franche-Comté [COMUE]
6 BFA (UMR_8251 / U1133) - Unité de Biologie Fonctionnelle et Adaptative
7 SU - Sorbonne Université

Preterm birth and its related complications have become more and more common as neonatal medicine advances. The concept of “developmental origins of health and disease” has raised awareness of adverse perinatal events in the development of diseases later in life. To explore this concept, we propose that encephalopathy of prematurity (EoP) as a potential pro-inflammatory early life event becomes a novel risk factor for metabolic diseases in children/adolescents and adulthood. Here, we review epidemiological evidence that links preterm birth to metabolic diseases and discuss possible synergic roles of preterm birth and neuroinflammation from EoP in the development of metabolic diseases. In addition, we explore theoretical underlying mechanisms regarding developmental programming of the energy control system and HPA axis.

Mots clés: Developmental programming; Metabolic disease; Preterm birth

Domaines: Alimentation et Nutrition

Sihao Diao, Chao Chen, Alexandre Benani, Christophe Magnan, Juliette van Steenwinckel, et al.. Preterm birth: A neuroinflammatory origin for metabolic diseases?. Brain, Behavior & Immunity - Health, 2024, 37, pp.100745. ⟨10.1016/j.bbih.2024.100745⟩. ⟨hal-04519223⟩